Over time, the sclera and the conjunctiva eventually “scar up” and the bleb is no longer functional.
Mitosol and Trabeculectomy
Trabeculectomy is performed to treat glaucoma, a disease that causes blindness, often due to increased pressure on the optic nerve caused by compromised outflow of aqueous humor from the anterior chamber of the eye. A portion of the trabecular meshwork is removed by the surgeon to create a bypass drain for the aqueous humor. The surgeon cuts the conjunctiva and separates it from the sclera, then creates a scleral flap to access the trabecular meshwork underneath. Once the portion of the trabecular meshwork is removed, aqueous outflow is established. The aqueous collects in the space between the sclera and conjunctiva, creating a bleb, where it is reabsorbed by the body.
Mitosol is Mitomycin C, an antimetabolite (a chemotherapy agent) that inhibits the growth of fibroblasts that cause scarring of those tissues. The surgeon applies Mitosol between the sclera and conjunctiva to target the fibroblasts and prevent bleb failure.
WMI-035 Rev 11/2019