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Trabeculectomy Procedure

September 10, 2017 by MitosolAdmin

Trabeculectomy Image.

What is a Trabeculectomy Procedure

A trabeculectomy is a surgical procedure performed by an ophthalmologist with the goal of relieving excessive pressure inside the eye, the leading symptom of glaucoma.

Trabeculectomy Steps

  1. The surgeon creates a hole from the inside of the eye to the outside of the eye, allowing fluid (aqueous humor) to drain out, lowering the pressure inside the eye.
  2. To prevent too much drainage, the surgeon creates a scleral flap that acts as a filter, regulating how much fluid can drain.

The fluid drains out from under the flap and is trapped between the sclera (the “white” of the eye) and the thin film covering the surface of the eye (conjunctiva), where it is absorbed by the body. By lowering the pressure inside the eye, compression on the optic nerve is reduced, preventing or slowing further damage to the optic nerve.

Procedure and Follow Up

The trabeculectomy procedure takes roughly an hour and is most often performed in an outpatient setting. It may be performed at the same time as cataract surgery, as some of the medications that treat glaucoma may contribute to cataract formation. It is common for the surgeon to apply mitomycin-c to the area which helps prevent scarring that could close the hole or flap. The surgeon will schedule several follow up appointments to make sure the intraocular pressure is at an optimal level and, if needed, make minor revisions to the flap to adjust the pressure.

Related Topics

  • What is Mitosol?

WMI-034 Rev 11/2019

Filed Under: Education Tagged With: glaucoma, trabeculectomy

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INDICATION

Mitosol® (mitomycin for solution) 0.2 mg/vial Kit for Ophthalmic Use is an antimetabolite indicated as an adjunct to ab externo glaucoma surgery.

Dosage & Administration

Mitosol® is intended for topical application to the surgical site of glaucoma filtration surgery and must be reconstituted prior to application. Sponges provided within the Mitosol® kit should be fully saturated with the entire reconstituted contents in a manner prescribed in the Instructions For Use. The sponge(s) should be applied to the treatment area for two minutes. Reconstituted Mitosol® should be used within one hour of reconstitution.

US Patents #7,806,265, #8,186,511, #D685,962, #D685,963, #9,205,075, #9,539,241 and #9,649,428; other international patents issued and pending.

Product Information

Please click here for full Product Information for Mitosol®

IMPORTANT SAFETY INFORMATION
Contraindications

Mitosol® is contraindicated in patients that have demonstrated a hypersensitivity to mitomycin and in women who are or may become pregnant during therapy.

Warnings & Precautions

Cell Death. Mitomycin is cytotoxic. Use of mitomycin in concentrations higher than 0.2 mg/mL or use for longer than 2 minutes may lead to unintended corneal and/or sclera damage including thinning or perforation. Direct contact with the corneal endothelium will result in cell death. Hypotony. The use of mitomycin has been associated with an increased instance of post-operative hypotony. Cataract Development. Use in phakic patients has been correlated to a higher instance of lenticular change and cataract formation.

Adverse Events & Reactions

The most frequent adverse reactions to Mitosol® occur locally and include hypotony, hypotony maculopathy, blebitis, endophthalmitis, vascular reactions, corneal reactions, and cataract. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit MedWatch, or call 1-800-FDA-1088.

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