Unfortunately, safe use during pregnancy has not been established. The following is a statement from the American Academy of Ophthalmology regarding use of MMC in pregnant/lactating patients.
“Mitomycin C is an antifibrotic agent which is frequently applied in glaucoma surgery. A decrease of mean litter size and body weight and an increase of exencephaly in second gestation mice were associated with mitomycin use.29 There are no studies reporting the teratogenic effect of this drug in the human fetus, though the mechanism of action of the drug strongly suggests a possible teratogenic risk.” -EyeWiki
Although this addresses use in pregnant patients, the issue is exposure to the drug. The Mitosol kit is designed to make the use of MMC in the operating room as safe as possible, however, there is always a potential for exposure, either by contact or inhalation. Therefore, we recommend that pregnant or nursing health care workers avoid working with it if possible. Due to the lack of information on chemotherapy and pregnant healthcare workers, our advice is it’s better to be safe than sorry.
WMI-038 Rev 01/2018